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Suppression of liver Apo E secretion leads to HDL/cholesterol immaturity in rats administered ethinylestradiol
http://hdl.handle.net/10659/00005404
http://hdl.handle.net/10659/0000540498bad033-e27e-4916-8980-07aa0a88130a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2017-103_Iwano.pdf (582.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-12 | |||||
| タイトル | ||||||
| タイトル | Suppression of liver Apo E secretion leads to HDL/cholesterol immaturity in rats administered ethinylestradiol | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Apo E | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cholesterol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | diethylstilbestrol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endocrine disruptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ethinylestradiol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | HDL | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamaguchi, Kosuke
× Yamaguchi, Kosuke× Ishii, Mariko× Maeda, Naoyuki× 岩野, 英知× Yokota, Hiroshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ethinylestradiol (EE), a main component of the combined oral contraceptive pill, is associated with an increased risk of arterial diseases. However, the toxicity mechanism of EE is poorly understood. In this study, we found that the exposure to EE reduced the serum apolipoprotein E (Apo E) level and high-density lipoprotein (HDL)/cholesterol concentration in adult female rats. Diethylstilbestrol showed the same effects and both reductions were suppressed by coadministration of tamoxifen (TAM). Liver perfusion experiments revealed that the secretion rate of Apo E from the liver was significantly reduced. It is concluded that EE damages the maturation of HDL/cholesterol by delaying Apo E secretion from the liver, and this may lead to an increased risk of arterial diseases, such as atheromas. | |||||
| 書誌情報 |
FEBS open bio 巻 6, 号 9, p. 928-936, 発行日 2016-09 |
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| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1002/2211-5463.12098 | |||||
| 権利（URI） | ||||||
| 権利情報 | https://creativecommons.org/licenses/by/4.0/ | https://creativecommons.org/licenses/by/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | John Wiley & Sons, Inc. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
