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Bacteriophage ΦSA012 Has a Broad Host Range against Staphylococcus aureus and Effective Lytic Capacity in a Mouse Mastitis Model
http://hdl.handle.net/10659/00006319
http://hdl.handle.net/10659/000063196a566b72-ef43-4e49-b858-a75a75a3c17d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2019-77_iwano.pdf (2.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-02-26 | |||||
| タイトル | ||||||
| タイトル | Bacteriophage ΦSA012 Has a Broad Host Range against Staphylococcus aureus and Effective Lytic Capacity in a Mouse Mastitis Model | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bacteriophage | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mastitis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Staphylococcus aureus | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | bacteriophage | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | mastitis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Staphylococcus aureus | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
岩野, 英知
× 岩野, 英知× Inoue, Yusuke× Takasago, Takuji× Kobayashi, Hironori× Furusawa, Takaaki× Taniguchi, Kotomi× 藤木, 純平× Yokota, Hiroshi× 臼井, 優× Tanji, Yasunori× 萩原, 克郎× 樋口, 豪紀× Tamura, Yutaka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Bovine mastitis is an inflammation of the mammary gland caused by bacterial infection in dairy cattle. It is the most costly disease in the dairy industry because of the high use of antibiotics. Staphylococcus aureus is one of the major causative agents of bovine mastitis and antimicrobial resistance. Therefore, new strategies to control bacterial infection are required in the dairy industry. One potential strategy is bacteriophage (phage) therapy. In the present study, we examined the host range of previously isolated S. aureus phages ΦSA012 and ΦSA039 against S. aureus strains isolated from mastitic cows. These phages could kill all S. aureus (93 strains from 40 genotypes) and methicillin-resistant S. aureus (six strains from six genotypes) strains tested. Using a mouse mastitis model, we demonstrated that ΦSA012 reduced proliferation of S. aureus and inflammation in the mammary gland. Furthermore, intravenous or intraperitoneal phage administration reduced proliferation of S. aureus in the mammary glands. These results suggest that broad host range phages ΦSA012 is potential antibacterial agents for dairy production medicine. | |||||
| 書誌情報 |
Biology 巻 7, 号 1, p. 8-1-8-13, 発行日 2018-01 |
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| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.3390/biology7010008 | |||||
| 権利 | ||||||
| 権利情報 | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. | |||||
| 権利（URI） | ||||||
| 権利情報 | https://creativecommons.org/licenses/by/4.0/ | https://creativecommons.org/licenses/by/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | MDPI | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
