WEKO3
アイテム
Effects of a high-fat diet on superoxide anion generation and membrane fluidity in liver mitochondria in rats
http://hdl.handle.net/10659/00006328
http://hdl.handle.net/10659/0000632853a83fb6-143c-4de7-92aa-ceb85254e506
名前 / ファイル | ライセンス | アクション |
---|---|---|
R-2019-100_yamaguchi.pdf (898.3 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-02-26 | |||||
タイトル | ||||||
タイトル | Effects of a high-fat diet on superoxide anion generation and membrane fluidity in liver mitochondria in rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | High-fat diet | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liver mitochondria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Superoxide anion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adrenaline method | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Membrane fluidity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Spin labels | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | High-fat diet | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Liver mitochondria | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Superoxide anion | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Adrenaline method | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Membrane fluidity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Spin labels | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Togo, M.
× Togo, M.× Konari, N.× Tsukamoto, M.× Kimoto, R.× Yamaguchi, T.× Takeda, H.× Kambayashi, I. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 【Background】 Obesity is a primary factor of lifestyle-related diseases, and the age of its onset has decreased. The reactive oxygen species (ROS), the superoxide anion, is generated in the mitochondrial electron transport chain and the damage it induces in cells may be a contributing factor to obesity-related lifestyle diseases. In the present study, the influence of the ingestion of a high-fat diet (HFD) on superoxide anion generation in rat liver mitochondria (Mt) and membrane fluidity was investigated.【Methods】 Male Wistar rats were fed a normal diet (ND, n = 6) or HFD (n = 6). Liver Mt were isolated and oxygen consumption, superoxide anion production (the adrenaline method), and membrane fluidity (the spin label method) were measured.【Results】 After 11 weeks, body weights and abdominal circumferences were higher in the HFD group than in the ND group. Mt oxygen consumption was higher in the HFD group than in the ND group. Superoxide anion production was significantly lower in the HFD group than in the ND group, while no significant changes were observed in membrane fluidity.【Conclusion】 Although rats developed diet-induced obesity, it did not reach the level of disease development. The promotion of lipid metabolism appeared to reduce superoxide anion production, but did not influence membrane fluidity. While superoxide anion damages cells as an oxidative stress, ROS and superoxide dismutase are essential signaling molecules in the body. The present results suggest that the continuous ingestion of a HFD impairs Mt and induces disease development. | |||||
書誌情報 |
Journal of the International Society of Sports Nutrition 巻 15, p. 13-1-13-8, 発行日 2018-03 |
|||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1186/s12970-018-0217-z | |||||
権利 | ||||||
権利情報 | © The Author(s). 2018 | |||||
権利(URI) | ||||||
権利情報 | http://creativecommons.org/licenses/by/4.0/ | http://creativecommons.org/licenses/by/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | BioMed Central Ltd | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |