WEKO3
アイテム
{"_buckets": {"deposit": "0608c6bc-f0fd-420a-abc3-087e6a8020ea"}, "_deposit": {"created_by": 3, "id": "2065", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "2065"}, "status": "published"}, "_oai": {"id": "oai:rakuno.repo.nii.ac.jp:00002065", "sets": ["29"]}, "author_link": ["4858", "4860", "4859"], "item_2_biblio_info_9": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "346", "bibliographicPageStart": "343", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "Biomedical Research"}]}]}, "item_2_description_43": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_2_description_6": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We investigated the anti-obesity effects of Brazilian green propolis ethanol extract using a mouse model of obesity. Repeated intraperitoneal injection of propolis (100 mg/kg twice a week) caused feeding suppression in C57BL/6 mice, whereas this treatment had negligible effects on C57BL/6 ob/ob mice. Since C57BL/6 ob/ob mice have a missense mutation in the Lep gene, leptin is likely to contribute to the propolis-induced feeding suppression. We found that propolis treatment indeed clearly increased leptin mRNA production in the visceral adipose tissues. Moreover, propolis extract directly elevated leptin expression in differentiated 3T3-L1 adipocytes. Artepillin C, an important organic compound found in Brazilian green propolis, failed to induce leptin mRNA in 3T3-L1 cells. Compounds other than artepillin C in Brazilian propolis must thus cause leptin induction in adipocytes, possibly resulting in the suppression of feeding and obesity.", "subitem_description_type": "Abstract"}]}, "item_2_publisher_36": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Biomedical Research"}]}, "item_2_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.2220/biomedres.36.343", "subitem_relation_type_select": "DOI"}}]}, "item_2_source_id_10": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1880-313X", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "WASHIO, Kohei"}], "nameIdentifiers": [{"nameIdentifier": "4858", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SHIMAMOTO, Yoshinori"}], "nameIdentifiers": [{"nameIdentifier": "4859", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "b81391484981e8e8d2b8301435373c47", "nameIdentifierScheme": "教員総覧", "nameIdentifierURI": "http://souran.rakuno.ac.jp/profile/ja.b81391484981e8e8d2b8301435373c47.html"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "KITAMURA, Hiroshi", "creatorNameLang": "en"}, {"creatorName": "北村, 浩", "creatorNameLang": "ja"}], "familyNames": [{"familyName": "KITAMURA", "familyNameLang": "en"}, {"familyName": "北村", "familyNameLang": "ja"}], "givenNames": [{"givenName": "Hiroshi", "givenNameLang": "en"}, {"givenName": "浩", "givenNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "4860", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9424", "nameIdentifierScheme": "教員総覧", "nameIdentifierURI": "https://www.rakuno.ac.jp/archives/teacher/9424.html"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-09-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "S-2016-149_kitamura.pdf", "filesize": [{"value": "261.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 261500.0, "url": {"label": "S-2016-149_kitamura.pdf", "url": "https://rakuno.repo.nii.ac.jp/record/2065/files/S-2016-149_kitamura.pdf"}, "version_id": "27872e51-142a-462a-a03e-0b697e0b35ae"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Brazilian propolis extract increases leptin expression in mouse adipocytes", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Brazilian propolis extract increases leptin expression in mouse adipocytes"}]}, "item_type_id": "2", "owner": "3", "path": ["29"], "permalink_uri": "http://hdl.handle.net/10659/4970", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-06-09"}, "publish_date": "2017-06-09", "publish_status": "0", "recid": "2065", "relation": {}, "relation_version_is_last": true, "title": ["Brazilian propolis extract increases leptin expression in mouse adipocytes"], "weko_shared_id": -1}
Brazilian propolis extract increases leptin expression in mouse adipocytes
http://hdl.handle.net/10659/4970
http://hdl.handle.net/10659/49704530f189-dc81-4b17-885b-ae491f9f79e0
名前 / ファイル | ライセンス | アクション |
---|---|---|
S-2016-149_kitamura.pdf (261.5 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-06-09 | |||||
タイトル | ||||||
タイトル | Brazilian propolis extract increases leptin expression in mouse adipocytes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
WASHIO, Kohei
× WASHIO, Kohei× SHIMAMOTO, Yoshinori× 北村, 浩 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the anti-obesity effects of Brazilian green propolis ethanol extract using a mouse model of obesity. Repeated intraperitoneal injection of propolis (100 mg/kg twice a week) caused feeding suppression in C57BL/6 mice, whereas this treatment had negligible effects on C57BL/6 ob/ob mice. Since C57BL/6 ob/ob mice have a missense mutation in the Lep gene, leptin is likely to contribute to the propolis-induced feeding suppression. We found that propolis treatment indeed clearly increased leptin mRNA production in the visceral adipose tissues. Moreover, propolis extract directly elevated leptin expression in differentiated 3T3-L1 adipocytes. Artepillin C, an important organic compound found in Brazilian green propolis, failed to induce leptin mRNA in 3T3-L1 cells. Compounds other than artepillin C in Brazilian propolis must thus cause leptin induction in adipocytes, possibly resulting in the suppression of feeding and obesity. | |||||
書誌情報 |
Biomedical Research 巻 36, 号 5, p. 343-346, 発行日 2015-10 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1880-313X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2220/biomedres.36.343 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Biomedical Research | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |