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Expression of the MDR1 gene and P-glycoprotein in canine mast cell tumor cell lines

http://hdl.handle.net/10659/1429
http://hdl.handle.net/10659/1429
cbdca490-0bb7-4156-af48-30c0e910d74b
名前 / ファイル ライセンス アクション
S-172_Kadosawa.pdf S-172_Kadosawa.pdf (1.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-03-11
タイトル
タイトル Expression of the MDR1 gene and P-glycoprotein in canine mast cell tumor cell lines
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 NAKAICHI, Munekazu

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WEKO 5722

NAKAICHI, Munekazu

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TAKESHITA, Yoko

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WEKO 5723

TAKESHITA, Yoko

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OKUDA, Masaru

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WEKO 5724

OKUDA, Masaru

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NAKAMOTO, Yuya

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WEKO 5725

NAKAMOTO, Yuya

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ITAMOTO, Kazuhito

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WEKO 5726

ITAMOTO, Kazuhito

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UNE, Satoshi

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WEKO 5727

UNE, Satoshi

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SASAKI, Nobuo

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WEKO 5728

SASAKI, Nobuo

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KADOSAWA, Tsuyoshi

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教員総覧 1017c99eddb77f9e0c0475b30845413d

KADOSAWA, Tsuyoshi

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TAKAHASHI, Tomoko

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WEKO 5729

TAKAHASHI, Tomoko

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TAURA, Yasuho

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WEKO 5730

TAURA, Yasuho

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抄録
内容記述タイプ Abstract
内容記述 Cellular drug resistance to antineoplastic drugs is often due to the presence of a drug efflux pump that reduces intracellular drug accumulation and chemosensitivity. P-glycoprotein (P-gp), which is encoded by the MDR1 gene, is considered to function as an ATP-driven membrane drug efflux pump and appears to play an important role in tumor cell resistance. In the present report, we assessed the expression of MDR1 by RT-PCR in three canine mast cell tumor cell lines, TiMC, CoMS and LuMC, originating from a cutaneous tumor, an oral-mucosal tumor and a gastrointestinal tumor, respectively. P-gp expression was also examined by Western blot analysis, while the functional activity of P-gp was assessed by flowcytometric analysis of intracellular rhodamine-123 (Rhd-123) uptake. The results revealed that MDR1 gene and P-gp were both expressed in CoMS and LuMC cells, whereas neither was present in TiMC cells. In CoMS and LuMC cells, intracellular uptake of Rhd-123 increased in the presence of verapamil, a functional modulator of P-gp. In contrast, TiMC cells did not show any changes in the intracellular accumulation of Rhd-123 after the verapamil addition. These findings suggest that the expressions of MDR1 gene and P-gp probably contribute to cellular drug resistance in canine mast cell tumors.
書誌情報 The Journal of Veterinary Medical Science

巻 69, 号 2, p. 111-115, 発行日 2007-02
ISSN
収録物識別子タイプ ISSN
収録物識別子 0916-7250
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 日本獣医学会
資源タイプ
内容記述タイプ Other
内容記述 Article
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