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Comparison of pharmacokinetics of tramadol between young and middle-aged dogs
http://hdl.handle.net/10659/00005421
http://hdl.handle.net/10659/000054211e500a5a-ee6e-4d19-997c-a36d707cde9a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2017-159_Yamashita.pdf (434.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-12 | |||||
| タイトル | ||||||
| タイトル | Comparison of pharmacokinetics of tramadol between young and middle-aged dogs | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dog | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | intravenous | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | middle-age | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pharmacokinetics | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tramadol | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
ITAMI, Takaharu
× ITAMI, Takaharu× SAITO, Yasuo× ISHIZUKA, Tomohito× TAMURA, Jun× UMAR, Mohammed A.× INOUE, Hiroki× 三好, 健二郎× 山下, 和人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study aimed to compare the pharmacokinetics of tramadol between young and middle-aged dogs. Tramadol (4 mg/kg) was administered intravenously (IV) to young and middle-aged dogs (2 and 8–10 years, respectively). Plasma concentrations of tramadol were measured using high-performance liquid chromatography (HPLC), and its pharmacokinetics best fit a two-compartment model. The volume of distribution (V_d), elimination half-life (t_<1/2,β>) and total body clearance (CL_<tot>) of the young group were 4.77 ± 1.07 l/kg, 1.91 ± 0.26 hr and 29.9 ± 7.3 ml/min/kg, respectively, while those of the middle-aged group were 4.73 ± 1.43 l/kg, 2.39 ± 0.97 hr and 23.7 ± 5.4 ml/min/kg, respectively. Intergroup differences in the t_<1/2,β> and CL_<tot> were significant (P<0.05). In conclusion, tramadol excretion was significantly prolonged in middle-aged dogs. | |||||
| 書誌情報 |
The Journal of veterinary medical science 巻 78, 号 6, p. 1031-1034, 発行日 2016-06 |
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| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 0916-7250 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1292/jvms.15-0638 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
