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Effects of interferon-τ on cattle persistently infected with bovine viral diarrhea virus
http://hdl.handle.net/10659/3488
http://hdl.handle.net/10659/3488ec0b6db6-f302-491b-8a2f-7fd4b0469754
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-2013-128_tajima.pdf (1.6 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-16 | |||||
| タイトル | ||||||
| タイトル | Effects of interferon-τ on cattle persistently infected with bovine viral diarrhea virus | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bovine viral diarrhea virus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cattle | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Interferon-τ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Persistent infection | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Kohara, Junko
× Kohara, Junko× Nishikura, Yumiko× Konnai, Satoru× Tajima, Motoshi× Onuma, Misao |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this study, the antiviral effects of bovine interferon-τ (boIFN-τ) on bovine viral diarrhea virus (BVDV) were examined in vitro and in vivo. In the in vitro experiments, the replication of cytopathic and non-cytopathic BVDV was inhibited in the bovine cells treated with boIFN-τ. The replication of BVDV was completely suppressed by boIFN-τ at a concentration higher than 10^<2> U/ml. In order to examine the effect of boIFN-τ on virus propagation in cattle persistently infected (PI) with non-cytopathic BVDV, boIFN-τ was subcutaneously administered to PI cattle at 10^<5> U/kg or 10^<6> U/kg body weight 5 times per week for 2 weeks. No physical abnormality such as depression was observed in the cattle during the experiment. The mean BVDV titers in the serum of the PI cattle decreased slightly during the boIFN-τ administration period with the dose of 10^<6> U/kg. However, the BVDV titers in the serum returned to the pre-administration level after the final boIFN-τ administration. These results suggest that boIFN-τ demonstrates an anti-BVDV effect, reducing the BVDV level in serum transiently when injected into PI cattle. | |||||
| 書誌情報 |
Japanese Journal of Veterinary Research 巻 60, 号 2&3, p. 63-70, 発行日 2012-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0047-1917 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Graduate School of Veterinary Medicine, Hokkaido University | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
