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Intestinal CD169^+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes
http://hdl.handle.net/10659/4987
http://hdl.handle.net/10659/498793e4b8af-7e7f-42ec-ad90-30229336dfd2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-2016-175_kitamura.pdf (2.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-06-09 | |||||
| タイトル | ||||||
| タイトル | Intestinal CD169^+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Asano, Kenichi
× Asano, Kenichi× Takahashi, Naomichi× Ushiki, Mikiko× Monya, Misa× Aihara, Fumiaki× Kuboki, Erika× Moriyama, Shigetaka× Iida, Mayumi× Kitamura, Hiroshi× Qiu, Chun-Hong× Watanabe, Takashi× Tanaka, Masato |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Lamina propria (LP) macrophages are constantly exposed to commensal bacteria, and are refractory to those antigens in an interleukin (IL)-10-dependent fashion. However, the mechanisms that discriminate hazardous invasion by bacteria from peaceful co-existence with them remain elusive. Here we show that CD169^+ macrophages reside not at the villus tip, but at the bottom-end of the LP microenvironment. Following mucosal injury, the CD169^+ macrophages recruit inflammatory monocytes by secreting CCL8. Selective depletion of CD169^+ macrophages or administration of neutralizing anti-CCL8 antibody ameliorates the symptoms of experimentally induced colitis in mice. Collectively, we identify an LP-resident macrophage subset that links mucosal damage and inflammatory monocyte recruitment. Our results suggest that CD169^+ macrophage-derived CCL8 serves as an emergency alert for the collapse of barrier defence, and is a promising target for the suppression of mucosal injury. | |||||
| 書誌情報 |
Nature Communications 巻 6, p. 7802-1-7802-14, 発行日 2015-07 |
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| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/ncomms8802 | |||||
| 権利（URI） | ||||||
| 権利情報 | https://creativecommons.org/licenses/by/4.0/ | https://creativecommons.org/licenses/by/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Macmillan Publishers Limited | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
