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Relationship between NF-κB Expression and Malignancy of Canine Mammary Gland Tumor Tissues
http://hdl.handle.net/10659/3454
http://hdl.handle.net/10659/3454be70ca2b-b121-4b6a-a0fb-80a3d40803b1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-2013-119_endo.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-16 | |||||
| タイトル | ||||||
| タイトル | Relationship between NF-κB Expression and Malignancy of Canine Mammary Gland Tumor Tissues | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | canine MGT | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | malignancy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NF-κB | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | prognosis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
MKAOUAR, Lobna
× MKAOUAR, Lobna× ENDO, Yoshifumi× JUN, He Xi× LEE, Soo-Jung× JAROENSONG, Tassanee× MOCHIZUKI, Manabu× UCHIDA, Kazuyuki× NAKAYAMA, Hiroyuki× SASAKI, Nobuo× NAKAGAWA, Takayuki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this study, the nuclear expression of nuclear factor kappa B (NF-κB) in 48 tissues specimens from 25 canine spontaneous mammary gland tumor (MGT) patients was assessed by immunohistochemistry to compare their levels with clinical features, histological types, prognostic outcomes and proliferative activities, including the mitotic index (MI) and cylcinD1 expression. Twelve of eighteen (66.7%) malignant tumor tissues showed greater than 10% nuclear staining, while benign tumor and hyperplastic tissues showed less than 10% nuclear staining. Higher nuclear expression of NF-κB was positively correlated with larger tumor size, lymph node metastasis and higher MI; however, no correlation was observed with distant metastasis and cyclin D1 expression. Higher NF-κB nuclear expression correlated with shorter patient survival. These findings suggest that NF-κB is a useful prognostic factor for canine MGT patients. | |||||
| 書誌情報 |
Journal of Veterinary Medical Science 巻 74, 号 6, p. 713-718, 発行日 2012-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0916-7250 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1292/jvms.11-0380 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
