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Serum big endothelin-1 as a clinical marker for cardiopulmonary and neoplastic diseases in dogs
http://hdl.handle.net/10659/4275
http://hdl.handle.net/10659/4275a6f12adc-c356-49b4-a24c-d76b13d8691a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-2015-210_miyasho.pdf (279.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2016-05-23 | |||||
| タイトル | ||||||
| タイトル | Serum big endothelin-1 as a clinical marker for cardiopulmonary and neoplastic diseases in dogs | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Big endothelin-1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Dog | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tumor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pulmonary hypertension | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Fukumoto, Shinya
× Fukumoto, Shinya× Hanazono, Kiwamu× Miyasho, Taku× Endo, Yoshifumi× Kadosawa, Tsuyoshi× Iwano, Hidetomo× Uchide, Tsuyoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 【Aims】 Many studies of human subjects have demonstrated the utility of assessing serum levels of endothelin-1 (ET-1) and big ET-1 as clinical biomarkers in cardiopulmonary and neoplastic diseases. In this study we explored the feasibility of using serum big ET-1 as a reliable veterinary marker in dogs with various cardiopulmonary and neoplastic diseases. 【Main methods】 Serum big ET-1 levels were measured by ELISA in dogs with cardiopulmonary (n = 21) and neoplastic diseases (n = 57). Dogs exhibiting cardiopulmonary disease were divided into two groups based on the velocity of tricuspid valve regurgitation (3.0 > m/s) measured by ultrasound: without and with pulmonary hypertension. Big ET-1 levels for the dogs with the diseases were compared with levels in normal healthy dogs (n = 17). 【Key findings】 Dogs with cardiopulmonary disease (4.6 ± 4.6 pmol/l) showed a significantly (P < 0.01) higher level of big ET-1 than healthy control dogs (1.1 ± 0.53 pmol/l). Serum levels in the dogs with pulmonary hypertension (6.2 ± 5.3 pmol/l) were significantly (P < 0.01) higher than those without pulmonary hypertension (2.0 ± 0.6 pmol/l). Dogs with hemangiosarcoma (5.6 ± 2.2 pmol/l), adenocarcinoma (2.0 ± 1.8 pmol/l), histiocytic sarcoma (3.3 ± 1.9 pmol/l), chondrosarcoma or osteosarcoma (3.0 ± 1.6 pmol/l) and hepatocellular carcinoma (2.7 ± 1.8 pmol/l) showed significantly (P < 0.05) higher levels than healthy control dogs. 【Significance】These findings point to the potential of serum big ET-1 as a clinical marker for cardiopulmonary and neoplastic diseases in dogs. | |||||
| 書誌情報 |
Life Sciences 巻 118, 号 2, p. 329-332, 発行日 2014-11 |
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| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.lfs.2014.01.002 | |||||
| 権利 | ||||||
| 権利情報 | © 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license | |||||
| 権利（URI） | ||||||
| 権利情報 | http://creativecommons.org/licenses/by-nc-nd/3.0/ | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier Inc. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
