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Collectin Kidney 1 Plays an Important Role in Innate Immunity against Streptococcus pneumoniae Infection
http://hdl.handle.net/10659/00005883
http://hdl.handle.net/10659/000058837e2e17ba-58e7-436b-9d1b-6832ab634cb8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2018-30_ohtani.pdf (402.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2019-08-08 | |||||
| タイトル | ||||||
| タイトル | Collectin Kidney 1 Plays an Important Role in Innate Immunity against Streptococcus pneumoniae Infection | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Collectin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Complement | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Innate immunity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Knockout mice | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pneumonia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Collectin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Complement | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Innate immunity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Knockout mice | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Pneumonia | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Hwang, Insu
× Hwang, Insu× Mori, Kenichiro× 大谷, 克城× Matsuda, Yasuyuki× Roy, Nitai× Kim, YounUck× Suzuki, Yasuhiko× Wakamiya, Nobutaka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Collectins are C-type lectins that are involved in innate immunity as pattern recognition molecules. Recently, collectin kidney 1 (CL-K1) has been discovered, and in vitro studies have shown that CL-K1 binds to microbes and activates the lectin complement pathway. However, in vivo functions of CL-K1 against microbes have not been elucidated. To investigate the biological functions of CL-K1, we generated CL-K1 knockout (CL-K1-/-) mice and then performed a Streptococcus pneumoniae infection analysis. First, we found that recombinant human CL-K1 bound to S. pneumoniae in a calcium-dependent manner, and induced complement activation. CL-K1-/- mice sera formed less C3 deposition on S. pneumoniae. Furthermore, immunofluorescence analysis in the wild-type (WT) mice demonstrated that CL-K1 and C3 were localized on S. pneumoniae in infected lungs. CL-K1-/- mice revealed decreased phagocytosis of S. pneumoniae. Consequently, less S. pneumoniae clearance was observed in their lungs. CL-K1-/- mice showed severe pulmonary inflammation and weight loss in comparison with WT mice. Finally, the decreased clearance and severe pulmonary inflammation caused by S. pneumoniae infection might cause higher CL-K1-/- mice lethality. Our results suggest that CL-K1 might play an important role in host protection against S. pneumoniae infection through the activation of the lectin complement pathway. | |||||
| 書誌情報 |
Journal of innate immunity 巻 9, 号 2, p. 217-228, 発行日 2017-03 |
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| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 1662-811X | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1159/000453316 | |||||
| 権利 | ||||||
| 権利情報 | © 2017 S. Karger AG, Basel | |||||
| 権利 | ||||||
| 権利情報 | The final,published version of this article is available at https://www.karger.com/Article/FullText/453316 | |||||
| 権利（URI） | ||||||
| 権利情報 | https://creativecommons.org/licenses/by-nc-nd/4.0/ | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Karger Publishers | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
