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Upregulation of PD-L1 Expression by Prostaglandin E_2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection
http://hdl.handle.net/10659/00007044
http://hdl.handle.net/10659/00007044519a0c93-06a0-4612-9a7c-79593471d55d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
R-2021-208_higuchi.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-02-21 | |||||
| タイトル | ||||||
| タイトル | Upregulation of PD-L1 Expression by Prostaglandin E_2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunoinhibitory molecules | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PD-1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PD-L1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | T-cell exhaustion | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | prostaglandin E_2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immune dysfunction | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mycoplasma bovis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cattle | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | immunoinhibitory molecules | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | PD-1 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | PD-L1 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | T-cell exhaustion | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | prostaglandin E_2 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | immune dysfunction | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Mycoplasma bovis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cattle | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Goto, Shinya
× Goto, Shinya× Konnai, Satoru× Hirano, Yuki× Kohara, Junko× Okagawa, Tomohiro× Maekawa, Naoya× Sajiki, Yamato× Watari, Kei× Minato, Erina× Kobayashi, Atsuhi× 権平, 智× 樋口, 豪紀× Koiwa, Masateru× 田島, 誉士× Taguchi, Eiji× Uemura, Ryoko× Yamada, Shinji× Kaneko, Mika K.× Kato, Yukinari× Yamamoto, Keiichi× Toda, Mikihiro× Suzuki, Yasuhiko× Murata, Shiro× Ohashi, Kazuhiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Bovine mycoplasmosis caused by Mycoplasma bovis results in pneumonia and mastitis in cattle. We previously demonstrated that the programmed death_1 (PD_<-1>)/PD-ligand _1 (PD-L_1) pathway is involved in immune dysfunction during M. bovis infection and that prostaglandin E_2 (PGE_2) suppressed immune responses and upregulated PD-L_1 expression in Johne's disease, a bacterial infection in cattle. In this study, we investigated the role of PGE_2 in immune dysfunction and the relationship between PGE_2 and the PD-1/PD-L1 pathway in M. bovis infection. In vitro stimulation with M. bovis upregulated the expressions of PGE_2 and PD-L_1 presumably via Toll-like receptor 2 in bovine peripheral blood mononuclear cells (PBMCs). PGE_2 levels of peripheral blood in infected cattle were significantly increased compared with those in uninfected cattle. Remarkably, plasma PGE_2 levels were positively correlated with the proportions of PD-L_1^+ monocytes in M. bovis-infected cattle. Additionally, plasma PGE_2 production in infected cattle was negatively correlated with M. bovis-specific interferon (IFN)-γ production from PBMCs. These results suggest that PGE_2 could be one of the inducers of PD-L1 expression and could be involved in immunosuppression during M. bovis infection. In vitro blockade assays using anti-bovine PD-L_1 antibody and a cyclooxygenase 2 inhibitor significantly upregulated the M. bovis-specific IFN-γ response. Our study findings might contribute to the development of novel therapeutic strategies for bovine mycoplasmosis that target PGE_2 and the PD_<-1>/PD-L_1 pathway. | |||||
| 書誌情報 |
Frontiers in Veterinary Science 巻 7, p. 12-1-12-14, 発行日 2020-02 |
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| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.3389/fvets.2020.00012 | |||||
| 権利（URI） | ||||||
| 権利情報 | http://creativecommons.org/licenses/by/4.0/ | http://creativecommons.org/licenses/by/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Frontiers Media SA | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
