WEKO3
アイテム
{"_buckets": {"deposit": "7b1958f3-1dc7-4bc4-9bcb-99819d135949"}, "_deposit": {"created_by": 3, "id": "2116", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "2116"}, "status": "published"}, "_oai": {"id": "oai:rakuno.repo.nii.ac.jp:00002116", "sets": ["29"]}, "author_link": ["5177", "4528", "5176", "4494"], "item_2_biblio_info_9": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "997", "bibliographicPageStart": "993", "bibliographicVolumeNumber": "69", "bibliographic_titles": [{"bibliographic_title": "The Journal of Veterinary Medical Science"}]}]}, "item_2_description_43": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_2_description_6": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The present study evaluated the costimulatory effects of complement receptor type 3 (CR3) and Fc receptor for IgG (FcγR) on superoxide production and intracellular signal transduction in bovine neutrophils. Stimulation with opsonized zymosan (OPZ) and heat-aggregated bovine IgG (Agg-IgG) resulted in much greater superoxide production and chemiluminescent (CL) responses in normal neutrophils compared with those stimulated with OPZ or Agg-IgG only. Superoxide production and CL response were closely associated with the stimulant-induced rise of the intracellular calcium ([Ca^2^+]_i) concentration, amount of tyrosine phosphorylated 100 kDa protein, and activation of p38 mitogen-activated protein kinase (p38 MAPK). No costimulatory effect was found for these receptors on superoxide production in CR3-deficient neutrophils. Costimulation of CR3 and FcγR on bovine neutrophils leads to enhancement of superoxide production and their signaling pathways and appears to be associated with enhancement of neutrophil functions.", "subitem_description_type": "Abstract"}]}, "item_2_publisher_36": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本獣医学会"}]}, "item_2_source_id_10": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0916-7250", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "NAGAHATA, Hajime"}], "nameIdentifiers": [{"nameIdentifier": "4528", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "cb22d3fb8f00ce528832880dc22347c6", "nameIdentifierScheme": "教員総覧", "nameIdentifierURI": "http://souran.rakuno.ac.jp/profile/ja.cb22d3fb8f00ce528832880dc22347c6.html"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "樋口, 豪紀", "creatorNameLang": ""}], "familyNames": [{"familyName": "樋口", "familyNameLang": ""}], "givenNames": [{"givenName": "豪紀", "givenNameLang": ""}], "nameIdentifiers": [{"nameIdentifier": "4494", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9415", "nameIdentifierScheme": "教員総覧", "nameIdentifierURI": "https://www.rakuno.ac.jp/archives/teacher/9415.html"}]}, {"creatorNames": [{"creatorName": "INANAMI, Osamu"}], "nameIdentifiers": [{"nameIdentifier": "5176", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KUWABARA, Mikinori"}], "nameIdentifiers": [{"nameIdentifier": "5177", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-09-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "S-181_Nagahata.pdf", "filesize": [{"value": "868.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 868300.0, "url": {"label": "S-181_Nagahata.pdf", "url": "https://rakuno.repo.nii.ac.jp/record/2116/files/S-181_Nagahata.pdf"}, "version_id": "bcdd4a81-0641-49ce-9ce3-956c0d8c7513"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Costimulating effects of complement receptor type 3 and Fc receptor for IgG(FcR) on superoxide production and signal transduction in bovine neutrophils", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Costimulating effects of complement receptor type 3 and Fc receptor for IgG(FcR) on superoxide production and signal transduction in bovine neutrophils"}]}, "item_type_id": "2", "owner": "3", "path": ["29"], "permalink_uri": "http://hdl.handle.net/10659/1452", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-03-11"}, "publish_date": "2010-03-11", "publish_status": "0", "recid": "2116", "relation": {}, "relation_version_is_last": true, "title": ["Costimulating effects of complement receptor type 3 and Fc receptor for IgG(FcR) on superoxide production and signal transduction in bovine neutrophils"], "weko_shared_id": -1}
Costimulating effects of complement receptor type 3 and Fc receptor for IgG(FcR) on superoxide production and signal transduction in bovine neutrophils
http://hdl.handle.net/10659/1452
http://hdl.handle.net/10659/14523f01e845-b2fe-4f96-b954-3b7b17ad5344
名前 / ファイル | ライセンス | アクション |
---|---|---|
S-181_Nagahata.pdf (868.3 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2010-03-11 | |||||
タイトル | ||||||
タイトル | Costimulating effects of complement receptor type 3 and Fc receptor for IgG(FcR) on superoxide production and signal transduction in bovine neutrophils | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
NAGAHATA, Hajime
× NAGAHATA, Hajime× 樋口, 豪紀× INANAMI, Osamu× KUWABARA, Mikinori |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The present study evaluated the costimulatory effects of complement receptor type 3 (CR3) and Fc receptor for IgG (FcγR) on superoxide production and intracellular signal transduction in bovine neutrophils. Stimulation with opsonized zymosan (OPZ) and heat-aggregated bovine IgG (Agg-IgG) resulted in much greater superoxide production and chemiluminescent (CL) responses in normal neutrophils compared with those stimulated with OPZ or Agg-IgG only. Superoxide production and CL response were closely associated with the stimulant-induced rise of the intracellular calcium ([Ca^2^+]_i) concentration, amount of tyrosine phosphorylated 100 kDa protein, and activation of p38 mitogen-activated protein kinase (p38 MAPK). No costimulatory effect was found for these receptors on superoxide production in CR3-deficient neutrophils. Costimulation of CR3 and FcγR on bovine neutrophils leads to enhancement of superoxide production and their signaling pathways and appears to be associated with enhancement of neutrophil functions. | |||||
書誌情報 |
The Journal of Veterinary Medical Science 巻 69, 号 10, p. 993-997, 発行日 2007-10 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0916-7250 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 日本獣医学会 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |