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Costimulating effects of complement receptor type 3 and Fc receptor for IgG(FcR) on superoxide production and signal transduction in bovine neutrophils
http://hdl.handle.net/10659/1452
http://hdl.handle.net/10659/14523f01e845-b2fe-4f96-b954-3b7b17ad5344
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S-181_Nagahata.pdf (868.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2010-03-11 | |||||
| タイトル | ||||||
| タイトル | Costimulating effects of complement receptor type 3 and Fc receptor for IgG(FcR) on superoxide production and signal transduction in bovine neutrophils | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
NAGAHATA, Hajime
× NAGAHATA, Hajime× 樋口, 豪紀× INANAMI, Osamu× KUWABARA, Mikinori |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study evaluated the costimulatory effects of complement receptor type 3 (CR3) and Fc receptor for IgG (FcγR) on superoxide production and intracellular signal transduction in bovine neutrophils. Stimulation with opsonized zymosan (OPZ) and heat-aggregated bovine IgG (Agg-IgG) resulted in much greater superoxide production and chemiluminescent (CL) responses in normal neutrophils compared with those stimulated with OPZ or Agg-IgG only. Superoxide production and CL response were closely associated with the stimulant-induced rise of the intracellular calcium ([Ca^2^+]_i) concentration, amount of tyrosine phosphorylated 100 kDa protein, and activation of p38 mitogen-activated protein kinase (p38 MAPK). No costimulatory effect was found for these receptors on superoxide production in CR3-deficient neutrophils. Costimulation of CR3 and FcγR on bovine neutrophils leads to enhancement of superoxide production and their signaling pathways and appears to be associated with enhancement of neutrophil functions. | |||||
| 書誌情報 |
The Journal of Veterinary Medical Science 巻 69, 号 10, p. 993-997, 発行日 2007-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0916-7250 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
